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KMID : 0606920060140040226
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Biomolecules & Therapeutics
2006 Volume.14 No. 4 p.226 ~ p.234
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Effect of Herbal Extracts Mixtures on Antioxidant System in Chronic Enthanol-treated Rats
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Kim Mok-Kyung
Won Eun-kyung
Choung Se-Young
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Abstract
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Disturbance of antioxidant system is very common in chronic alcoholics and herbal or natural prod- ucts with antioxidant activity have been used for its treatment. This study was to investigate the effect of Vitis vin- ifera extract (V), Schisandra chinensis (S), Taraxacum, officinale (T), Gardenia jasminoides extract (G), Angelica acutiloba extract (A) and Paeonia japonica extract (P), and their combinations on the antioxidant and ethanol oxidation system. Male Sprague-Dawley rats were subjected to Lieber-DeCarli ethanol liquid diet (ED) and were then given different herbal extract mixtures for 6 weeks including VST(V 100 + S 150 +T 150 mg/kg/day) VSG (V 100 + S 150 + G 150 mg/kg/day). VTG (V 100 + T 150 + G 150 mg/kg/day), and VAP (V 100 + A 150 + P 150 mg/kg/day). When the activity of alcohol dehydrogenase (ADH) and acetaldehyde dehy- drogenase (ALDH) were compared between ED only group and herbal extracts treatment group, the differences were statistically significant. Phase Ⅰ and Ⅱ (glutathione S transferase, phenol sulfatransferase) enzyme activities were found to be significantly higher in the VAT treatment grup compared to the ED group. Herbal extracts not only repressed the ethanol-induced elevation of malondialdehyde level, but also protected against ethanol-induced decrease in glutathione content, glutathione reductase, glutathione peroxidase, catalase and superoxide dismulase activities. The administration of the herbal extracts was forund to be effective in eliminating lipid-peroxides induced by long-term consumption of alcohol by activating various enzyme systems and physiological active compound formation system. After a chronic consumption of alcohol. Angelica Radix protected the liver via acti- vating the ethanol-metabolism enzyme system, and Paeoniae Radix via activating the ethanol-metabolism enzyme and the phase Ⅰ, Ⅱ-metabolism enzyme system. Taraxaci Herba was also effective in liver protection via activating the ethanol-metabolism enzyme system and the phase Ⅰ, Ⅱ-metabolism enzyme system, Gardeniae Fructus via activating the phase Ⅱ-metabolism enzyme system and the anti-oxidation system enzyme, and Schisandra Fructus and a grapestone via activating the anti-oxidation system. Our data suggest that these herbal extracts may be useful as a health functional food or new drug candidate for fatty liver and hepatotoxicity induced by chronic alcohol consumption.
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KEYWORD
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Vitis vinifera, Schisandra chinensis, Taraxacum officinale, Gardenia jasminoides, Angelica acutiloba, Paeonia japonica, ethanol liquid diet, antioxidant
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